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As I said, it's a working hypothesis- one (rough) way to explain the observed data.
There are two datum points which to me are anchors:
1) Saruman did indeed breed human-orc hybrids. This is not merely Treebeard's opinion, but something Tolkien explicitly stated.
2) The Uruk-hai at Helm's Deep declare proudly that the Sun doesn't bother them in the slightest: and the only explanation offered anywhere for such a thing lies in an admixture of Mannish genes.
From these two postulates I think it flows necessarily that Saruman bred some part of his Uruks with human stock. What proportion or which ones is much thornier territory.
(BTW: I'm fully prepared to condider Ghrishnakh and his band 'fully-trained soildier-Orcs', i.e. Uruk-hai. Their running performance is as astounding as Ugluk's, if not more so.)
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The entire plot of The Lord of the Rings could be said to turn on what Sauron didn’t know, and when he didn’t know it.
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